Theoph
Pharmacokinetic Study of Theophylline
Description
Data from a study by Dr. Robert Upton of the kinetics of the
anti-asthmatic drug Theophylline. Twelve subjects were given oral
doses of Theophylline then serum concentrations were measured at 11
time points over the next 25 hours.
Usage
Theoph
Value
This data frame contains the following columns:
| Subject |
a factor identifying the subject.
|
| Wt |
weight of the subject (kg).
|
| Dose |
dose administered to the subject (mg/kg).
|
| time |
time since drug administration when the sample was drawn (hours).
|
| conc |
Theophylline concentration in the sample (mg/L).
|
Source
These data are reported in Boeckmann, Sheiner, and Beal (1992),
"NONMEM User's Guide, Part V, Introductory Guide", University of
California, San Francisco and in Davidian and Giltinan (1995),
"Nonlinear Models for Repeated Measurement Data", Chapman and Hall,
London.
See Also
Examples
Theoph.1 <- Sdatasets::Theoph[ Sdatasets::Theoph$Subject == 1, ]
fm1 <- nls(conc ~ SSfol(Dose, Time, lKe, lKa, lCl), data = Theoph.1)
summary(fm1)