Indometh
Pharmacokinetics of Indomethicin

### Description

Data on the plasma concentrations of Indomethicin following intravenous injection. There are six different subjects in the experiment and the times of sampling are the same for each subject. These times range from 15 minutes post injection to 8 hours post injection.

### Usage

    Indometh

Value
This data frame contains the following columns:

Subject | a factor indicating the subject from whom the sample is drawn.
time | time at which the sample was drawn (hr. post injection).
conc | observed plasma concentration of indomethicin (mcg/ml).

Source
These data are given in Kwan, Breault, Umbenhauer, McMahon, and Duggan (1976), "Kinetics of Indomethicin absorption, elimination, and enterohepatic circulation in man", Journal of Pharmacokinetics and Biopharmaceutics, 4, 255--280. They are analyzed in section 2.1 of Davidian and Giltinan (1995), "Nonlinear Models for Repeated Measurement Data", Chapman and Hall, London.
See Also
Indometh.plot, biexp, nlsList, nlme.
Examples

    Indometh.6 <- Sdatasets::Indometh[Sdatasets::Indometh$Subject == 6,]
    nls(conc ~ SSbiexp(time, A1, A2, lrc1, lrc2), data = Indometh.6)

Package Sdatasets version 6.1.5-18
Package Index