The most important part of the Spotfire environment to back up is the Spotfire database.

It contains tables which store the state of the server, for example the library, preferences, and deployments. Most of the server and service configuration files are also stored in the database. Even if only the database has been backed up, it is still possible to restore most of the functionality after a crash. It is therefore vital that you have a valid and current backup of the Spotfire database.